Aceites esenciales : para recuperar la vitalidad, el by Francesco Padrini, Maria Teresa Lucheroni.

By Francesco Padrini, Maria Teresa Lucheroni.

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Once an information need is recognized, a well-structured clinical question can be formulated, and that question can be used to search for information in an organized way. Since all information is not created equal, the next step is to critically appraise any information found to determine whether it is valid and applicable to the patient at hand. If so, it can be applied to the individual patient. In the case of a therapy, for example, its application must take into account the patient’s baseline risk for certain outcomes and how he or she values the potential risks and benefits of the therapy.

Even when it is available, questions have also been raised about the quality of evidence. Some studies are never published, some studies are designed to obtain a particular result, and in a few instances, results may even be falsified. Finding information to answer specific questions sometimes feels like looking for a needle in a haystack. 9 Use of these “methodologic hedges” dramatically improves the relevance of the articles retrieved, and these terms are incorporated into PubMed in the Clinical Queries screen (see Chapter 3 on searching for more detail).

Publication bias may result for a number of reasons. Studies with positive results are more likely to be published than studies with negative results, making it appear from reviews of the published literature that certain treatments are more effective than is truly the case. Other sources of publication bias include duplicate publication, failure to publish completed trials, publication in the non-English language, and publication in journals not listed in MedLine (see Chapter 1). Randomization A “formal chance” process (equivalent to the flip of a coin) by which children participating in a study are allocated to groups.

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