By Oscar Bodansky, C. P. Stewart
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Extra info for Advances in Clinical Chemistry, Vol. 11
Frederikson, K. , Significance of serum iron in differential diagnosis between gastric carcinoma and peptic ulcer. Acta Med. Smnd. 146, 259-267 (1953). F15. Freireich, E. , Emerson, C. , and Ross,J. , The effect of inflammation on the utilization of erythrocyte and transferrin iron for hemoglobin synthwis. J. Clin. Invest. 84, 934 (1955). G1. , and Walker, A. R. , Serum iron and iron-binding capacity in the South African Bantu. Nature 171, 699 (1953). G2. , and Walker, A. R. , The effect of habitually high iron intake on certain blood values in pregnant Bantu women.
In such a case anemia comes first, to be followed later by depletion of iron stores only if absorption fails to meet the emergency. By contrast, slow blood loss may lead to the utilization of stored iron before anemia is sufficiently marked to stimulate iron absorption. There is a good deal of evidence that the alimentary tract may show disorders which are corrected by iron administration when anemia is mild or even absent (Dl, H14, W7). When frank iron deficiency has fully developed, the plasma iron is almost always very low.
M. Copper and iron metabolism in the nephrotic syndrome. J . Clin. Invest. 33, 685498 (1954). C6. Caton, W. , Roby, C. , Reid, D. , Maletskos, C. , Fluharty, R. , and Gibson, J. , The circulating red cell volume and body hematocrit in normal pregnancy and the puerperium. Am. J. Obstet. Gynecol. 61, 1207-1217 (1951). C7. Christian, E. , Behaviour of the serum iron in various diseases of the liver. A . M . A . Arch. Internal Med. 94, 22-33 (1954). D1. Darby, W. , Oral manifestations of iron deficiency.