Amyotrophic Lateral Sclerosis: A Synthesis of Research and by Andrew Eisen, Charles Krieger

By Andrew Eisen, Charles Krieger

Amyotrophic Lateral Sclerosis, another way often called Lou Gehrig's ailment, is among the many degenerative illnesses of the getting older apprehensive approach. this article well synthesizes the new explosion of analysis into this actual to build an in depth and accomplished evaluation. Drs. Eisen and Krieger deliver their learn services and broad medical adventure to supply this sensible and thought-provoking account. Chapters conceal the epidemiology, molecular biology, and pathophysiology of ALS, in addition to matters pertinent to medical overview and care.

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It also shows the 75th and 95th upper prediction bounds on disease duration at each age, and the corresponding life expectancy for the population of British Columbia for the years 1993-1995. 7. Kaplan-Meier survival curves by sex (top) and age (bottom). The survival curves are not significantly different for men and women. Age has a significant effect on survival of ALS, with patients who have a young onset living longer. 02). 0001). (From Eisen et al. (1993b). Muscle & Nerve, 16; 27-32. 2. 4 Percentile After Eisen et al (1993c).

The associations were greatly increased, with the odds ratios for developing PD adjusted for age, gender, race and smoking history exceeding that for any exposure to one metal alone. 008). It may be that these metals, especially in combination, promote oxidative stress by means of free radical generation (Olanow and Arendash, 1994). This study is the first to document PD and the association of metal exposure after 20 years. It is also the first to consider exposures to combinations of metals. Similarfindingscould be applicable to ALS, and epidemiological studies directed to long-term exposure are certainly warranted.

The apparently high familial incidence of lytico-bodig seemed to point to a hereditary disorder. However, epidemiology of the 22 Epidemiological considerations disease is inconsistent with Mendelian inheritance (Kurland and Molgaard, 1982). Even so, a susceptibility gene could be present among the Chamorros. Mutations of the copper/zinc-superoxide dismutase (Cu/Zn-SOD) gene have not been described in Guamanian ALS (Chen, 1995). 2. -N-methylamino-L-alanine (BMAA) or cycasin (methylazoxymethanol b-D-glucoside) to animals has not induced motoneuron disease.

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